cancer’s growth and spread Cells responsible for bladder cancer’s spread identified

By Live Dr - Fri Aug 07, 4:28 pm

Washington, Aug 7 (ANI): John Hopkins researchers have identified a powerful set of cells in bladder tumours that appears to be primarily responsible for the cancer’s growth and spread.

The researchers have long suspected that a subset of cells in cancerous tumours act much like developmentally primitive cells known as stem cells, which spur organ development early in life and remain present in nearly all the body’s organs to repair or replace injured and aging tissues.

These cancer cells and stem cells share a variety of characteristics including an unlimited lifespan and a propensity to migrate through tissues.

Dr David Berman, associate professor of pathology, oncology, and urology at the Johns Hopkins University School of Medicine said that these same properties are the ones that make cancer particularly dangerous.

If researchers find a way to identify and specifically target cancer cells with these properties, they could wipe out the population that sustains tumours and makes them grow.

The researchers reasoned that if these stem-like cancer cells behave like healthy stem cells, they might be physically located in the same compartments in tissue where stem cells normally reside.

During the study, using a surface protein marker previously identified for healthy bladder stem cells, the Hopkins team searched for cells with the same marker in sections from 55 human bladder tumours.

They found that cancer cells displaying the marker were localized in an area at the intersection of two layers of cells known as epithelium and stroma, the place where bladder stem cells are typically located.

Using cancer cell lines grown from other bladder cancer patients, the researchers separated cells displaying the stem cell marker from those without it and injected these two different sets of mice.

The mice injected with the cancer cells displaying the marker always grew tumours, but those injected with the other cancer cells rarely did, suggesting that the stem-like cancer cells have an ability to create new tissue much like healthy stem cells do.

The study also showed that genes linked to cell proliferation and metastasis were most active in stem-like cells than in the other cancer cells.

The findings appear in journal Stem Cells (ANI)


Comments 251 - 253 of 253First« PrevNext »Last
  1. best online casino best online casinos casino online | [url=https://onlinecasino888.us.org/]casino games[/url]

  2. g2CjFP Muchos Gracias for your blog post.Really looking forward to read more. Really Great.

  3. payday lender loan lenders payday loan direct lender [url=https://cashnow.cars]lender[/url]

  4. lender instant payday loans for bad credit direct lender installment loans [url=https://cashnow.cars]online payday loan reviews[/url]

  5. personal loans quick loan lenders fast cash loans with no credit check [url=https://cashnow.cars]loans online direct lenders[/url]

  6. payday loans direct lender payday loans direct lender payday loans direct lender [url=https://cashnow.cars]payday loans direct lender[/url]

  7. For hottest news you have to visit world-wide-web and on the web I found this website as
    a best website for latest updates.

    Chelsea ny trøje

  8. I love reading a post that can make people think.

    Also, thanks for permitting me to comment!

    Liverpool fotbollströja barn

Comments 251 - 253 of 253First« PrevNext »Last

Leave a Reply