fat weight loss diet pills side effects and pharmacologist Dieter defects patients with health problems

By Live Dr - Sat Apr 11, 3:43 pm


Taking herbal food supplements is certainly not free of risk. Since
2005, the poison emergency centers in the German cities of Freiburg and
Gottingen have registered a total of 17 patients with health problems
after taking Chinese slimming capsules. 


The pharmacologist Dieter M?and his coauthors describe the documented cases of poisoning in the current edition of Deutsches ?zteblatt International (Dtsch Arztebl Int 2009; 106(13): 218-22).
The authors report on a slimming pill on sale over the Internet.
According to the advertising, this contains herbal substances and is
declared as a food supplement. However, examination of the formulation
has shown that it also contains the active substance sibutramine, which
resembles amphetamine and which inhibits the reuptake of serotonin and
noradrenaline in the brain. The sibutramine dose in each capsule
corresponded to twice the daily maximum dose of the prescription drug
in Germany.
Fifteen women and two men exhibited symptoms of poisoning, including
nausea, tachycardia, headache, agitation, dyspnea, and insomnia. A
14-year old girl had to be admitted to a psychiatric ward because of
acute confusion. A man developed a psychosis after taking the capsules.
Severe symptoms of poisoning mainly occurred in combination with other
Patients often fail to inform their doctors that they are taking
herbal products, as they regard these as harmless. Dieter M?assumes
that the consumption of food supplements containing sibutramine is much
greater than has been recorded. Moreover, the causal connection is not
recognized in many cases and the poison information center is not
consulted. The authors therefore urge that manufacturers should be
obliged to declare ingredients and doses.


The U.S. Food and Drug Administration has approved Coartem tablets
(artemether and lumefantrine) for the treatment of acute, uncomplicated
malaria infections in adults and children weighing at least five
kilograms (approximately 11 pounds).
"Malaria is a global life-threatening disease," said Murray M.
Lumpkin, M.D., deputy commissioner for International and Special
Programs, FDA. "It is encouraging to have new treatment available,
particularly for children."
Coartem is not approved for the treatment of severe malaria nor to
prevent malaria. Severe malaria is different than acute, uncomplicated
malaria in that patients with severe malaria have altered consciousness
and other metabolic and end-organ complications. These patients are not
candidates for oral drugs and should be given intravenous anti-malarial

Malaria is a serious public health problem in many parts of the
world. Persons from the United States who live in or travel to
high-incidence areas are at risk of infection. Malaria is transmitted
when a person is bitten by an infected mosquito. Coartem has been shown
to be effective in geographical regions with reported resistance to
chloroquine, a drug that prevents and treats malaria.
"Because of concerns about drug resistance with currently available
drug therapy, it will benefit patients to have another treatment option
for malaria available," said Edward Cox, M.D., M.P.H, director of the
Office of Antimicrobial Products in the FDA's Center for Drug
Evaluation and Research.
Symptoms of malaria include fever, chills, and flu-like illness.
Left untreated, the disease can cause severe complications, including
death. About 90 percent of malaria deaths occur in Sub-Saharan Africa,
but the disease is also prevalent in parts of Asia and Latin America.
It is estimated that 350 to 500 million new cases develop worldwide
annually and 1 million patients, primarily young children, die of the
Coartem should be taken with food, particularly food that contains fat, because this allows the body to absorb the drug well.
The most common adverse reactions to Coartem shown in clinical
trials in adults are headache, anorexia, dizziness, physical weakness
(asthenia), joint pain (arthralgia) and muscle pain (myalgia). The most
common adverse reactions reported in children are fever (pyrexia),
cough, vomiting, loss of appetite, and headache.
Artemether, one of the active ingredients in Coartem tablets, is the
first artemesinin class drug approved in the United States. The
artemesinins are derived from the leaves of the Artemisia annua plant
that are used to treat malaria.
In compliance with a provision of the Food and Drug Administration
Amendments Act of 2007, the FDA awarded Novartis a one-time priority
review voucher to use towards a future new drug application. The
provision, which was designed to encourage development of drugs to
treat tropical diseases, authorizes the granting of such vouchers to
sponsors of treatments for certain tropical diseases. The voucher may
be transferred by the recipient to another manufacturer.
Coartem is made by Novartis Pharmaceuticals Corporation, Basel, Switzerland.


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