11/21/2018

First Biological Laser Made From A Single Living Cell

By Live Dr - Mon Jun 13, 10:47 pm

Researchers at Harvard Medical School and Massachusetts General Hospital built a living laser partly to study interactions between electronic and biological systems, and partly out of sheer curiosity. The world’s first biological laser, made from a single living cell, could lead to better microscope imaging inside the body and even targeted light therapies, researchers say.

A single human cell engineered to express green fluorescent protein can be used to amplify photons into super-short pulses of laser light, the researchers say.

You Light Up My Life Green laser light shines from a human kidney cell modified to express green fluorescent protein. Malte Gather

Lasers consist of a gain medium, the source of optical gain within the laser which absorbs external energy and excites atoms or molecules into a more energized state, inside an optical cavity. Most lasers use semiconductors, crystals or gases as a gain medium. In this case, the researchers used green fluorescent protein (GFP).

First, the researchers filled an inch-long cylinder with a GFP solution, and placed mirrors at each end. They pulsed it with light and confirmed the GFP solution could amplify the input energy into short pulses of laser emissions, according to a news release from Mass. General. This proved GFP could serve as the laser’s gain medium. Green fluorescent protein, isolated from jellyfish, will emit green light when it is exposed to blue light.

Then the team engineered human embryonic kidney cells to produce GFP, and placed a single cell between two mirrors, just 20 micrometers apart. The researchers flooded the cell with blue light, and the cell lit up. The mirrors served as the optical cavity, allowing light to bounce through the cell many times, amplifying it into a coherent green beam that was visible to the naked eye.

Living Laser Schematic: When a single biological cell genetically programmed to produce green fluorescent protein is placed inside an optical resonator consisting of two parallel mirrors separated by 20 µm (0.02 mm), the cell can generate green laser light.  Nature Photonics/Malte Gather, Wellman Center for Photomedicine, Massachusetts General Hospital

The cell’s spherical shape acted as a lens, refocusing the light and therefore requiring less energy for lasing than was necessary in the cylinder experiment. Best of all, the cells survived the lasing process, and were able to produce hundreds of pulses of laser light.

A living laser could have a wide range of medical uses, according to lead author Malte Gather at the Wellman Center for Photomedicine at Mass. General. They could be used to activate drugs using light, for instance, or for new forms of imaging — it is difficult for visible and UV light to penetrate very far inside the body. Eventually, living lasers could enable optical communications and computing inside the body, using living systems instead of electronics.

Link

92 Comments

Comments 51 - 92 of 92First« PrevNext »Last
  1. You could certainly see your expertise within the work you write. The arena hopes for more passionate writers like you who are not afraid to say how they believe. At all times go after your heart.

  2. Wow, stunning website. Thnx …

  3. Terrific website you have here.

  4. You’ve got great information here.

  5. ought to take on a have a look at joining a word wide web based romantic relationship word wide web website.

  6. slot machines for sale view of Three Gorges | Wonder Travel Blog

  7. Pretty! This was an incredibly wonderful article. Thanks for supplying this info.

  8. It as not that I want to copy your web page, but I really like the pattern. Could you let me know which theme are you using? Or was it custom made?

  9. Thanks for sharing this very good article. Very interesting ideas! (as always, btw)

  10. Say, you got a nice blog post.Thanks Again. Great.

  11. It as difficult to find knowledgeable people on this subject, however, you sound like you know what you are talking about! Thanks

  12. I truly appreciate this post. I ave been looking everywhere for this! Thank goodness I found it on Bing. You have made my day! Thank you again..

  13. There is noticeably a bundle to know about this. I assume you made sure nice factors in features also.

  14. This page certainly has all the info I needed about this subject and didn at know who to ask.

  15. Say, you got a nice article post.Much thanks again. Fantastic.

  16. Major thanks for the article post.Much thanks again. Want more.

  17. we came across a cool web site which you could love. Take a appear when you want

  18. Im thankful for the blog article.Really looking forward to read more. Really Cool.

  19. This unique blog is without a doubt cool additionally diverting. I have picked up a bunch of interesting advices out of this blog. I ad love to come back again soon. Cheers!

  20. Many thanks, this site is very handy.

  21. I wanted to thank you for this good read!! I definitely enjoyed every bit of it. I have you book-marked to look at new things you post

  22. This blog is without a doubt awesome and besides factual. I have picked helluva helpful advices out of this blog. I ad love to come back again soon. Cheers!

  23. Souls in the Waves Very good Early morning, I just stopped in to visit your site and believed I would say I enjoyed myself.

  24. Saved as a favorite, I really like your website!

  25. thank so considerably for your site it helps a lot.

  26. This particular blog is without a doubt entertaining and also factual. I have found many useful stuff out of this amazing blog. I ad love to visit it again soon. Thanks!

  27. Quite Right I definitely liked the article which I ran into.

  28. Very neat blog article.Really thank you! Keep writing.

  29. Your style is unique compared to other people I have read stuff from. Thank you for posting when you ave got the opportunity, Guess I will just book mark this site.

  30. Many thanks, this site is really useful.

  31. I was recommended this web site by my cousin.

  32. I was suggested this web site by my cousin. I am not sure whether this post is written by him as no one else know such detailed about my trouble. You are incredible! Thanks!

  33. very good submit, i certainly love this website, keep on it

  34. It is appropriate time to make a few plans for the long run and it is time to be happy.
    I’ve learn this put up and if I may I want to recommend you few fascinating issues or tips.
    Maybe you could write next articles relating to this article.

    I wish to read more things about it!

    Valencia drakt

  35. Hi there, just became aware of your blog through Google,
    and found that it’s truly informative. I’m gonna watch out for brussels.
    I will appreciate if you continue this in future.
    A lot of people will be benefited from your writing.
    Cheers!

    Arsenal ny trøje

  36. Some really choice blog posts on this web site , saved to fav.

  37. Some truly good blog posts on this internet site, appreciate it for contribution.

  38. My blog addresses a lot of the same subjects as yours and I feel

  39. Say, you got a nice blog article.Really thank you! Fantastic.

  40. The Birch of the Shadow I believe there may be a couple of duplicates, but an exceedingly useful listing! I have tweeted this. Many thanks for sharing!

  41. Spot on with this write-up, I truly think this website needs much more consideration. I?ll probably be again to read much more, thanks for that info.

Comments 51 - 92 of 92First« PrevNext »Last

Leave a Reply