09/24/2017

HIV, blood cancer patients mechanism behind the prevention

By Live Dr - Thu Apr 02, 7:07 am

New hope for HIV, blood cancer patients

A Canadian scientist has discovered a mechanism that stops regeneration of white blood cells that play a vital role in keeping up the body’s immune system.
New hope for HIV, blood cancer patients
But these white blood cells – called CD4+T lymphocytes in medical parlance – are destroyed massively during chemotherapy and bone marrow transplant required for patients suffering from leukaemia or blood cancers. The destruction of white cells leads to weakening of the immune system, leaving patients vulnerable to various infections.
Immunity can then take many years to regenerate. But Marten Guimond of the University of Montreal’s –Maisonneuve-Rosemont Hospital has identified the mechanism that stops the regeneration of these white cells, giving fresh hope to patients whose immune system is weakened after undergoing intensive chemotherapy, receiving bone marrow transplants, or getting infected with HIV.
In a release, the university said Guimond’s study has identified a negative regulation loop that restricts the ability of white cells to divide.
“By acting on this regulation loop, we can create a homeostatic production of CD4+ T lymphocytes (white cells) that will allow the immune system to regenerate,” the statement quoted Guimond as saying.
The study of the associate researcher in the University of Montreal’s Department of Microbiology and Immunology was published in the prestigious journal Nature Immunology Tuesday.
Source: Indo-Asian News Service

London, Jan 13 (ANI): In a new study, scientists have uncovered the mechanism behind the prevention of the regeneration of CD4+ T lymphocytes, which are white cells that are required for the proper functioning of the immune system.

The finding by Dr. Martin Guimond, from the Universite de Montreal and the Maisonneuve-Rosemont Hospital, may greatly influence patients who undergo intensive chemotherapy, receive bone marrow transplants or become infected with HIV.

Normally, chemotherapy and bone marrow transplants are considered to be effective methods to treat patients suffering from leukaemia or other blood cancers.

However, owing to the massive destruction of T lymphocytes, such treatments cause a major weakening of the immune system.

While immunity can then take many years to regenerate, it could leave patients highly vulnerable to infections.

Guimond’’s study identified a negative regulation loop that restricts the ability of T lymphocytes to divide.

“By acting on this regulation loop, we can create a homeostatic production of CD4+ T lymphocytes that will allow the immune system to regenerate,” Nature quoted Guimond, as saying.

The study was published in the prestigious journal Nature Immunology. (ANI)

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