Insignia: A New Way To Identify Viruses And Bacteria

By Live Dr - Wed Jul 06, 1:20 pm

Now that the genome sequences of hundreds of bacteria and viruses are known, we can design tests that will rapidly detect the presence of these species based solely on their DNA. These tests can detect a pathogen in a complex mixture of organic material by recognizing short, distinguishing sequences–called DNA signatures–that occur in the pathogen and not in any other species.

Adam Phillippy and colleagues from the University of Maryland, USA, have developed a computer program that can identify these signatures with a higher degree of accuracy than ever before. They describe this new computational system, called Insignia, and the results of its successful application on 46 Vibrio cholerae strains this week in the Open Access journal PLoS Computational Biology.

Insignia uses highly efficient algorithms to compare known bacterial and viral genomes against each other and to background genomes including plants, animals, and humans. These comparisons are stored in a database and used to rapidly compute signatures for any particular target species. The program can have a wide range of applications, from diagnosing infections in humans to detecting harmful microbes in a water supply. To maximize its use by scientists in a variety of disciplines, Insignia is freely available on the authors’ website (http://insignia.cbcb.umd.edu).

Bacterial and viral pathogens have always represented one of the greatest threats to human health, and in recent times this threat increased due to the possibility of engineered biological agents. The genome sequencing field has targeted and sequenced the complete genomes of hundreds of bacteria and thousands of viruses over the past decade, which now make it possible to develop programs like Insignia, capable of detecting any given virus or bacterium by its DNA pattern in a sample.

Article:  Phillippy AM, Mason JA, Ayanbule K, Sommer DD, Taviani E, et al. (2007) Comprehensive DNA signature discovery and validation. PLoS Comput Biol 3(5): e98. doi:10.1371/journal.pcbi.0030098



Comments -49 - 0 of 45First« PrevNext »Last
  1. HO1esh Thanks for sharing, this is a fantastic post.Much thanks again. Fantastic.

  2. Perfectly indited content , regards for information.

  3. Fantastic Website, Carry on the wonderful work. Thanks a lot.|

  4. Simply just want to express I am just thankful that i happened on your website.|

  5. If some one desires expert view concerning running a blog after

  6. You have noted very interesting details ! ps decent web site. He that will not sail till all dangers are over must never put to sea. by Thomas Fuller.

  7. Really enjoyed this blog post.Really thank you!

  8. I love this website – its so usefull and helpfull.

  9. Simply wanted to stress I am just relieved I stumbled in your webpage!|

  10. Merely wanted to emphasize Now i’m happy that i came onto your web site!|

  11. Great internet website! It looks extremely good! Sustain the helpful work!

  12. Terrific Post.thanks for share..much more wait..

  13. Highly informative look forth to visiting again.

  14. You’re a very helpful website; couldn’t make it without ya!

  15. pals ans additionally sharing in delicious. And of

  16. stays on topic and states valid points. Thank you.

  17. Thanks, I have recently been searching for facts about this subject for ages and yours is the best I ave found so far.

  18. IE still is the marketplace chief and a large portion of other people will leave out

  19. Wow, wonderful blog layout! How long have you been blogging for? you make blogging look easy. The overall look of your site is great, as well as the content!. Thanks For Your article about sex.

  20. Very good information. Lucky me I found your website by accident (stumbleupon). I have bookmarked it for later!

  21. I think this is a real great article.Really thank you! Great.

  22. Looking forward to reading more. Great article post.Really thank you! Cool.

  23. Thanks regarding providing these good written content.

  24. Keep up the great job and generating the group!

  25. I like browsing your web sites. Many thanks!

  26. I delight in the info on your web site. Thnx.

  27. Thanks meant for giving these sort of superb content material.

  28. You’ve gotten possibly the best web sites.

  29. The stuff is really important.

  30. Thanks so much for the blog post.Really thank you! Cool.

  31. Woh I like your blog posts, saved to bookmarks !.

  32. There is definately a great deal to know about this subject. I love all the points you ave made.

  33. This awesome blog is without a doubt educating and factual. I have chosen helluva helpful stuff out of it. I ad love to come back over and over again. Thanks a lot!

  34. Respect to op , some good selective information.

  35. There is evidently a bunch to know about this. I feel you made some nice points in features also.

  36. Your style is so unique compared to other people I ave read stuff from. I appreciate you for posting when you have the opportunity, Guess I will just book mark this page.

  37. This is one awesome post.Really thank you! Much obliged.

  38. This is one awesome blog.Thanks Again. Cool.

  39. I went over this web site and I believe you have a lot of great info, saved to favorites (:.

  40. Thanks extremely handy. Will certainly share site with my good friends.

  41. You have mentioned very interesting points ! ps decent website. I am going to a special place when I die, but I want to make sure my life is special while I am here. by Payne Stewart.

  42. This is a topic that is near to my heart Cheers! Exactly where are your contact details though?

  43. Well I really liked reading it. This tip provided by you is very useful for good planning.

  44. Remarkable issues here. I am very happy to

Comments -49 - 0 of 45First« PrevNext »Last

Leave a Reply