ONCOLOGY mci screening test and indian medical pg examz high yield important topics study tips

By Live Dr - Wed Feb 11, 3:26 am


highly radiosensitive tumors highly radioresistant

Ewing’s tumor


Wilm’s tumor

Multiple myeloma





Pancreatic cancer

*Most radiocurable tumor is Hodgkin’s disease

biological fractionation of radiotherapy is explained by
Repair of sublethal damage

Repopulation between fractions

Redistribution of cells in the cell cycle

Reoxygenation of tumor

Inherent Radiosensitivity

Recruitment of cells into the proliferating fraction

*Most radiosensitive portion of cell cycle

G2 – M phase

*Penetrating power

Gamma > X-ray> Beta > Alpha (Helium)

Ionizing power and damaging power

Alpha (Helium) > Beta > X-ray > Gamma

*Thimble chamber-Used for detection and measurement of radiation


Tc-99m 6 hrs
I 131 8 days
I 125 60 days
Co-60 5.2 yrs
Ra 226 1699 years
CML t (9,22)
Burkitt’s lymphoma t (8, 14)
Ewing’s tumour t (11,22)
Acute promyelocytic leukemia t (15,17)


God heals, and the doctor takes the fees.- Benjamin Franklin

ELEVENTH HOUR ONCOLOGY                                                                                                             228

tumour marker associated tumours
HCG Trophoblastic tumours, nonseminomatous testicular tumours
Calcitonin Medullary carcinoma of thyroid
Alpha fetoprotein Liver cell cancer, nonseminomatous germ cell tumours of testis
Carcinoembryonic antigen Carcinoma colon, pancreas, lung, stomach, breast
Acid phosphates


Prostate cancer
Neuron specific Enolase Small cell lung cancer, Neuroblastoma
Immunoglobulins Multiple myeloma
CA 125 Ovarian cancer
Ca 19-9 Colon cancer, pancreatic cancer
Ca 15-3 Breast cancer
5-hydroxy indole acetic acid Carcinoid tumors
Serum alkaline phosphatase Osteosarcoma
Homovanillic acid, VMA Neuroblastoma, pheochromocytoma
Ca 50 / Ca 242 Colorectal, pancreatic, gastric.
Neuron specific Enolase Neuroendocrine  tumours

Small cell lung carcinomas

Medullary thyroid carcinomas

*Characteristic of AML- Auer rods

Philadelphia chromosome – CML

*Commonest malignancy in women in developing countries is cervical cancer

Commonest malignancy in women in developed countries is breast cancer

Commonest cancer in elderly is prostrate cancer.

Burkitt’s lymphoma -most rapidly progressive tumour.

Most common inherited malignancy is retinoblastoma

Tumor suppressor genes

Rb Retinoblastoma and osteogenic sarcoma
P53 Many tumors and Li Fraumeni syndrome
Wt 1 Wilm’s tumor and aniridia
Nf1 Neurofibromatosis

*P53 is the guardian of genome

P53 mutation is the most common genetic alteration seen in human cancer

It is the causative in Li-Fraumeni familial cancer syndrome


The rosy periwinkle plant, found in Madagascar, is used to cure leukemia

ELEVENTH HOUR ONCOLOGY                                                                                                         229

chemical associated cancer
Benzene Leukemias
Vinyl chloride Angiosarcoma of liver
Beta-naphthylamine Urinary bladder carcinoma
Azo dyes Hepatoma
Aflatoxin Hepatoma
Hypernephroma (renal cell carcinoma)

Cerebellar hemangioblastoma


Adrenal adenoma



Uterine fibromyoma

Ann Arbor staging for Hodgkin’s disease

Stage I Involvement of single lymph ode region
Stage II Involvement of 2 or more lymph node regions on same side of diaphragm
Stage III Involvement of lymph node regions on both sides of diaphragm
Stage IV Disseminated involvement of one or more extra lymphatic organs with or without.

*Trousseau’s sign of malignancy / Trousseau’s syndrome

Some malignancies, especially adenocarcinomas of the pancreas and lung, are associated with hypercoagulability. In patients with malignancy-associated hypercoagulable states, the blood may spontaneously form clots in the portal vessels, the deep veins of the extremities, or the superficial veins anywhere on the body. When recurrent clots form in different superficial veins around the body, this is described as migratory thrombophlebitis.

Armand Trousseau first described this finding in himself; he was subsequently found to have pancreatic cancer.

*Mesna- Sodium 2-mercapto ethane sulphate

Protective agent in cancer chemotherapy (Cyclophosphamide) to prevent hemorrhagic cystitis

Acrolein is thought to be responsible for its action

*Kaposi’s sarcoma is the most common neoplasm in patients with AIDS


An invincible determination can accomplish almost anything and in this lies the great distinction between great men and little men. – Dr. Thomas Fuller

ELEVENTH HOUR ONCOLOGY                                                                                                           230


Comments 51 - 65 of 65First« PrevNext »Last
  1. Loving the info on this site, you have done outstanding job on the articles.

  2. It is best to take part in a contest for among the best blogs on the web. I all recommend this site!

  3. Really appreciate you sharing this article.Much thanks again. Want more.

  4. Normally I do not learn article on blogs, however I would like to say that this write-up very pressured me to try and do it! Your writing style has been surprised me. Thank you, quite nice post.

  5. Say, you got a nice blog post.Really looking forward to read more. Great.

  6. With thanks! It a terrific webpage!

  7. One of our guests not long ago recommended the following website.

  8. Really appreciate you sharing this article.Thanks Again.

  9. I think this is a real great blog post. Fantastic.

  10. Here are a few of the web pages we recommend for our visitors

  11. that could be the end of this article. Right here youll obtain some web sites that we think you will enjoy, just click the links over

  12. You need to take part in a contest for among the best blogs on the web. I will advocate this website!

  13. the time to read or visit the subject material or internet sites we have linked to beneath the

  14. What web host are you the use of? Can I get your associate hyperlink in your host?

  15. Thanks for sharing such a fastidious opinion, piece of writing is pleasant, thats why i have read
    it completely

    maglia Chelsea poco prezzo

Comments 51 - 65 of 65First« PrevNext »Last

Leave a Reply