12/16/2018

Too Much Energy Can Lead To Heart Failure

By Live Dr - Sun Jul 10, 11:37 am

The amount of energy available to a cell is controlled by the protein AMPK, which senses when a cell has low levels of energy and triggers the cell to generate more. Mutations in one of the AMPK subunits (gamma-2) leading to increased AMPK activity are associated with heart failure characterized by the accumulation of high levels of the energy source glycogen in heart muscle cells.

However, the mechanisms by which these mutations lead to heart failure have not been defined.

In a study that appears online on April 12 in advance of publication in the May print issue of the Journal of Clinical Investigation, Rong Tian and colleagues from Brigham and Women’s Hospital, Boston, used mice expressing one of the mutant forms of the gamma-2 AMPK subunit in heart muscle cells to show that increased AMPK activity is associated with altered metabolism in the heart muscle cells.

The cells were found to take up an increased amount of glucose and to store this as glycogen, leading to increased amounts of glycogen in the heart muscle cells. This effect of AMPK is of clinical relevance since it suggests that activation of AMPK, which is being considered as a potential treatment for type 2 diabetes, might lead to heart failure.

Link:Sciencedaily.com

127 Comments

Comments 101 - 127 of 127First« PrevNext »Last
  1. iOS app developer blues | Craft Cocktail Rules

  2. What the amazing post you ave made. I merely stopped into inform you I truly enjoyed the actual read and shall be dropping by from time to time from right now on.

  3. I’а†ve read several excellent stuff here. Certainly value bookmarking for revisiting. I surprise how so much attempt you set to make one of these fantastic informative web site.

  4. Major thankies for the blog.Much thanks again. Fantastic.

  5. We stumbled over here different website and thought I should check things out. I like what I see so now i am following you. Look forward to looking at your web page for a second time.

  6. Ridiculous quest there. What occurred after? Thanks!

  7. Really enjoyed this blog post.Much thanks again. Cool.

  8. Very neat article.Thanks Again. Great. porno gifs

  9. Say, you got a nice blog article.Really thank you! Cool.

  10. May you please prolong them a bit from next time? Thanks for the post.

  11. Informative article, exactly what I needed.

  12. Major thankies for the article post.Really thank you! Great.

  13. running shoes brands running shoes outlet running shoes for beginners running shoes

  14. That is a very good tip particularly to those fresh to the blogosphere. Short but very precise info Thanks for sharing this one. A must read article!

  15. Hey, thanks for the blog post.Really looking forward to read more. Really Great.

  16. There as definately a lot to learn about this issue. I love all the points you have made.

  17. An impressive share! I have just forwarded this onto a co-worker who has been conducting a little
    research on this. And he actually bought me breakfast simply because I discovered it for him…

    lol. So let me reword this…. Thanks for the meal!!
    But yeah, thanx for spending some time to discuss this topic here on your website.

    barcelona drakt med trykk

  18. Very good article. I definitely appreciate this site. Thanks!

  19. I’а†ve learn several excellent stuff here. Certainly worth bookmarking for revisiting. I wonder how a lot attempt you set to make the sort of wonderful informative web site.

  20. A round of applause for your article.Much thanks again. Want more.

  21. I truly appreciate this post. I ave been looking everywhere for this! Thank goodness I found it on Bing. You ave made my day! Thanks again.

  22. I think this is a real great article post. Awesome.

  23. to be using? I am having some small security problems with

  24. Merely a smiling visitant here to share the love (:, btw great style and design. Justice is always violent to the party offending, for every man is innocent in his own eyes. by Daniel Defoe.

  25. Too many times I passed over this link, and that was a mistake. I am pleased I will be back!

  26. Retain up the terrific piece of function, I read few content material on this website and I think that your web weblog is actual intriguing and has got circles of good info .

  27. Heya i’m for the primary time here. I found this board and I in finding It truly helpful & it helped me out
    a lot. I’m hoping to give one thing again and aid others such as
    you aided me.

    Atletico Madrid drakt

Comments 101 - 127 of 127First« PrevNext »Last

Leave a Reply